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It slows and impairs cognition and reaction time and the cognitive skills, impairs judgement, interferes with motor function resulting in motor incoordination, loss of balance, confusion, sedation, numbness and slurred speech, impairs memory formation, and causes sensory impairment
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Moreover, a counterintuitive reduction in N-terminal pro B-type natriuretic peptide concentrations on top of weight reduction has been shown in both STEP HFpEF trials, indicating potential direct cardiac effects of the therapies