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Delivers a compound MoA comparison matrix useful for prioritising lead candidates before committing to resource-intensive target identification

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it freely crosses the cell membrane and inhibits UCP2-mediated proton leakage in mitochondria, increases the mitochondrial membrane potential, increases ATP levels, and closes K (ATP) channels without affecting other mitochondrial functions (Zhang et al., 2006)

doi:10.1016/j.preteyeres.2018.06.002 OHollaren P

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