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Chronic Insomnia: In an open-label study involving patients with severe chronic insomnia, a treatment regimen of 10 intravenous injections of DSIP (25 nmol/kg) resulted in a normalization of sleep patterns that persisted for follow-up periods of 3 to 7 months.Crucially, the patients reported not just improved sleep duration, but improved daytime mood and performance, distinguishing DSIP from benzodiazepines which often cause daytime drowsiness and cognitive impairment

6 Athira Pharma LIFT-AD topline results (press release)September 3, 2024 announcement that fosgonimeton (a distinct HGF/c-Met modulator) did not meet the primary or key secondary endpoints in the Phase 2/3 LIFT-AD Alzheimers trial

Only log-transformed variables were tested in a single analysis

Liposomes can fuse with cellular membranes, dumping their cargo directly into the cell or facilitating endosomal escape if internalized, a process significantly more efficient than passive diffusion of the free peptide

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