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HSA has low-affinity and high-binding capacity for TH and binds the remaining 10%20% of serum T3 and T4

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Tirzepatide offers dual agonist activity, targeting both GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) receptors, which may contribute to its enhanced weight loss efficacy compared to single-receptor agonists

Some patients report better symptom control when they avoid drinking large amounts immediately before or during meals, as this can increase gastric distension

There have also been reports of visual problems and unknown risks when these drugs are combined with other medications, such as antidepressants or blood-pressure treatments