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By activating the GLP-1 receptors, these medications help control blood sugar, reduce appetite, and improve insulin sensitivity

Retatrutide-related nausea, reduced appetite, vomiting, or diarrhea can also make it harder to stay hydrated

Do not use semaglutide if you have a personal or family history of medullary thyroid carcinoma (MTC) or MEN2

The Phase 2 trial did show that gradual titration significantly reduces GI side effects

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Thermally processed oil exaggerates colonic inflammation and colitis-associated colon tumorigenesis in mice