Gastrointestinal side effects: Nausea, vomiting, and diarrhoea which are frequently reported in trial data can lead to dehydration and electrolyte imbalances, both of which may contribute to fatigue
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NICE guidelines for weight management emphasise evidence-based interventions including dietary modification, increased physical activity, behavioural therapy, and in appropriate cases, pharmacological treatments (such as orlistat or semaglutide) or bariatric surgery
262,263,264 Specific competitive inhibitor of NAMPT could ameliorate the immunity or inflammatory disorders, including DSS-induced colitis, arthritis via reducing intracellular NAD + levels in inflammatory cells and circulating inflammatory cytokines, including IL-1beta, TNF-alpha, and IL-6
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