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Saxenda should be used with a reduced-calorie meal plan and increased physical activity Saxenda is not for the treatment of type 2 diabetes Saxenda and Victoza have the same active ingredient, liraglutide, and should not be used together Saxenda should not be used with other GLP-1 receptor agonist medicines Saxenda and insulin should not be used together It is not known if Saxenda is safe and effective when taken with other prescription, over-the-counter, or herbal weight-loss products It is not known if Saxenda changes your risk of heart problems or stroke or of death due to heart problems or stroke It is not known if Saxenda can be used safely in people who have had pancreatitis It is not known if Saxenda is safe and effective in children under 18 years of age

These occurrences commonly take place in the initial weeks of treatment, notably as the dosage escalates

A randomized trial found that low-dose semaglutide significantly decreased: The amount of alcohol consumed during laboratory self-administration tasks 22 Weekly alcohol cravings compared to placebo 22 Drinks per drinking day 22 The magnitude of these effects appears substantial, with medium to large effect sizes for grams of alcohol consumed (, 0.48) and peak breath alcohol concentration (, 0.46) 22

Metabolic improvements beyond weight loss also become measurable during this window

GLP-1 drugs have been used by large shares of adults who say they have been diagnosed with diabetes (57% have ever used the drug, including 45% who are currently using), heart disease (40% ever, 29% currently), or as obese or overweight in the past five years (34% ever, 23% currently)

It is unclear whether these neural anti-inflammatory actions of GLP-1 medicines rely on GLP-1R activity