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Some protocols incorporate cycling, using a 5-days-on, 2-days-off schedule to maintain pituitary sensitivity and prevent receptor downregulation

[42] and Li et al

The low-affinity IgE binding Fc receptor (CD23) is expressed on B-cells, its soluble (truncated) form is generated by proteolytic cleavage and regulates IgE production of B-cells

New Formulations: Efforts are underway to create more convenient formulations, including longer-acting injectables that may only require monthly administration and improved oral versions

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