The vascular endothelium plays a pivotal role in maintaining vascular tone, regulating fibrinolytic and thrombotic activity, and preventing leukocyte and platelet adhesion (3)
While compounded medications are not FDA-approved, they are often used when branded medications are in short supply or when a patient requires a specific dosage or formulation not available commercially
For example, individuals with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) should not use GLP-1 medications
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The JAMA article mentioned above recognizes that during such situations the anesthesiologist and surgeon must take special precautions to avoid aspiration
Oestrogen production falls sharply, while androgen levels decline less, creating relative androgenicity and an adverse cardiometabolic profile [134]