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Across the Phase 2 and Phase 3 trials, heart rate increased by approximately 6.7 bpm at the 12 mg dose, peaking around week 24 and declining thereafter

Molteni, Chen)

Therefore, peptide analogs of GLP-1 have been developed to treat type 2 diabetes and obesity, with the beneficial outcome of lowering cardiovascular risks 10,11

It is part of why retatrutide is studied as a broader metabolic compound rather than only an appetite tool

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However, it has not achieved the same level of success as stand-alone GLP-1 receptor agonists like semaglutide and dulaglutide