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The inflammatory environment is known to alter junctional proteins and barrier function of the epithelium

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Both transcriptional and post-transcriptional mechanisms modulate the activity of this critical cellular enzyme.

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Decanoic acid is able to modulate astrocyte metabolism directly, leading to activation of the astrocyte-neuron lactate shuttle and providing fuel to neighboring neurons in the form of lactate (130, 131)

Activated protein C inhibits tissue plasminogen activatorinduced brain hemorrhage