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1 Smaller amounts of GLP-1 are also produced by neurons in the nucleus tractus solitarius (NTS) of the brainstem, thus highlighting its dual role in both peripheral and central metabolic regulation

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Concerns about the potential association between certain diabetes medications and cardiovascular disease meant that in 2010 the FDA approved liraglutide on condition that Novo Nordisk conduct a post-marketing study to evaluate the drug's effect on the incidence of major cardiovascular events (Nielsen, DeChiaro, Goldman)

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