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Thermodynamic studies reveal that MT3 binds Cu + through enthalpy-driven processes and Zn + via entropy-driven mechanisms, forming Cu 4 thiolate clusters

Atluri H, Mullin J, Takahashi K, Loghavi S, Maiti A, Sasaki K, Daver N, Valero YA, Pemmaraju N, Borthakur G, Hammond DE, Chien KS, Ferrajoli A, Short NJ, Abbas HA, Jabbour E, Andreeff M , Ravandi F, Tidwell RSS, Wang X, Konopleva MY, Garcia-Manero G, Kantarjian HM, DiNardo CD

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Hepatology 35, 13201328