Important safety considerations include: Diabetic retinopathy complications : Patients with pre-existing diabetic retinopathy should be monitored closely, particularly during rapid improvement in glucose control Gallbladder disease : Semaglutide has been associated with an increased risk of cholelithiasis and cholecystitis Acute pancreatitis : Patients should seek immediate medical attention if they experience severe, persistent abdominal pain that may radiate to the back, often accompanied by vomiting Dehydration and acute kidney injury : The gastrointestinal effects may lead to dehydration, which can cause acute kidney injury
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Mounjaro is typically initiated at a low dose (2.5 mg weekly) and gradually increased over several weeks to minimise gastrointestinal side effects, which are among the most commonly reported adverse reactions
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