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GLP-1 and GIP receptors present in the brain offer a direct target for improved metabolic function [14,15]

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In this context, GLP1R is associated with a lineage plastic mRNA phenotype where AR and Notch signaling are downregulated, supporting trans-differentiation from an adenocarcinoma to a neuroendocrine-differentiated cancer

Dudum also told investors that the company is open to a partnership like the one its rival Ro has with Eli Lilly $LLY, which lets Ro offer its members cheaper Zepbound in vials rather than the standard auto-injector pens