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When cells are over-nutrient and hyperglycemic, the excessive NADH produced by the polyol pathway will promote the production of superoxide through the overload complex I of ETC, resulting in cell dysfunction and impaired insulin secretion

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Idh1 mutations contribute to the development of T-cell malignancies in genetically engineered mice

Sorour NE, Abd El-Kareem HM, Ibrahim AE, Salem RM