Our Approach Personalized Care for Sustainable Weight Management Tailored treatment plans for sustainable habits Physician-led care with labs and EKG monitoring Ongoing support from a dedicated health coach Ideal Candidate BMI of 30 and above, or BMI of 27+ with at least one weight-related condition, such as controlled hypertension, diabetes, or high cholesterol Men and women age 18 or older Ready to lose the weight and keep it off for good
Administered via a once-weekly injection, semaglutide offers convenience and flexibility for patients, allowing them to integrate the treatment into their lifestyle while working towards their health goals
Stimulating GLP-1R in BMSCs triggers the buildup of nuclear -catenin, which, in turn, activates osteogenic genes by binding with TCF7L12.371 In osteoblasts, the administration of GLP-1 and GIP incretins suppressed the excessive expression of the pro-degradative enzymes MMP-3 and MMP-13 induced by IL-1 stimulation.372 In vitro, GLP-1 disrupts the ability of osteoblasts to survive and differentiate by triggering the activation of c-Fos, which is a proto-oncogene.373 In fact, when BMSCs are exposed to exendin-4, the expression of genes related to bone development factors such as Runx and Osterix, as well as genes responsible for producing the bone matrix such as Balp and Bglap, is upregulated
In a randomized trial published in the New England Journal of Medicine, 1,879 adult patients with type 2 diabetes were assigned to once-weekly injections of either tirzepatide (at 5 mg, 10 mg, or 15 mg) or semaglutide 1 mg for 40 weeks
Ela inclui gua corporal, ossos, rgos e tecido muscular
reported that suppressing AA metabolism by using COX-2, 5-LOX, and CYP4A in macrophages under GA conditions shifted the macrophages away from the M1 phenotype (65)
