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26 There are also potentially synergistic interactions between the short-term satiety signal cholecystokinin (CCK) and leptin, which may involve integration at the level of primary sensory afferents

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Mean insulin secretion rate versus glucose concentration in patients with type 2 diabetes during graded glucose infusion before (baseline) and after 12 weeks of treatment with semaglutide or placebo and in untreated healthy subjects During induced hypoglycemia, semaglutide did not alter the counter regulatory responses of increased glucagon compared to placebo and did not impair the decrease of C-peptide in patients with type 2 diabetes