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Studies with caffeine/xanthine administration through any route (oral, intraperitoneal, intravenous, subcutaneous, or intracerebral)

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Coating agent: Vegetable cellulose

While nuclear factor erythroid 2-related factor 2 (NRF2) and CCAAT/Enhancer Binding Protein (CEBP) also contribute to a minor increase in CHAC1 transcription, their roles are less pronounced compared to ATF4 ( FIGURE 4 ATF4 and ATF3 regulate CHAC1 expression by binding to specific sites within its promoter, the ATF/cAMP response element (CRE) at position 267 and the ATF/CRE modifier (ACM) motif at 248

doi: 10.1038/s42255-022-00531-x 21 JacobsenLMDigginsKBlanchfieldLMcNicholsJPerryDJBrantJet al