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However, current evidence is mainly derived from preclinical studies, and further investigations, particularly rigorous clinical trials in humans, are necessary to clarify the mechanisms involved and to evaluate their efficacy and safety in patients with cutaneous melanoma

Fernndez-Checa JC and Kaplowitz N (1990)

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It produces sustained rise of growth hormone and IGF-1 levels through continuous boost of growth hormone release

Advanced degenerative conditions severely degenerated cartilage or end-stage joint disease involves tissue that may be beyond repair acceleration