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Notwithstanding, TIR alleviated memory impairment in STZ-induced diabetic rats by modulating insulin resistance and the inflammatory response through restoration of the PI3K/Akt/GSK-3 signaling pathway (Guo et al., 2023)

The APOE-TR model is a mouse knock-in model where exons 24 (comprising the mouse APOE gene) are replaced with human APOE in 129xC57BL/6 mice back-crossed to C57BL/6 mice (Sullivan et al., 1997)

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Hsieh from The University of Texas Southwestern Medical Center for tissue slide preparation

And thereby, their biomechanic assessment demonstrated markedly higher intestine strength before leaking ( Figs