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Detailed analysis of these crystal structures combined with molecular dynamics studies reveal that there are channels (the main ones around 40-45 long) leading from the catalase surface to the active sites [Dominguez, 2010

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Williams reported that while central blockade of the GLP-1 system with ICV administration of exendin 939 blocked the actions of central but not peripheral GLP-1, peripheral (intraperitoneal) exendin 939 blocked the appetite-suppressing actions of peripheral, but not central GLP-1, indicating that the two systems do not depend on each other for activity

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Hydroperoxides, such as hydrogen peroxide and lipid hydroperoxides, act as substrates for these enzymes [28]