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Orskov et al., 1993), which helps prevent over production of insulin and hypoglycemia

demonstrated that oxidative stress induced bovine GC apoptosis by increasing the expression of cleaved caspase-3 and the Bax/Bcl-2 ratio as well as decreasing the expression of antioxidant enzymes (SOD2, glutathione peroxidase (GSH-Px)) (Wang Y et al., 2019)

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Finally, the diabetic kidney may be predisposed to chronic tissue hypoxia, in part due to impaired renal perfusion secondary to hyperglycemia-associated microvascular damage

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