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Lancet 393 , 3139 (2019)

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Early integration of chemistry, manufacturing, and controls considerations into translational planning is therefore essential to avoid late-stage attrition

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Observational studies in humans report lower circulating spexin levels in obesity and metabolic syndrome, supporting its role as an endogenous metabolic regulator rather than a stress-induced peptide (Lv et al., 2019)

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