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Markowicz-Piasecka M, Markiewicz A, Darak P, Sikora J, Adla SK, Bagina S, Huttunen KM (2022) Current chemical, biological, and physiological views in the development of successful brain-targeted pharmaceutics

Storage matters more here than it does for a robust small molecule, because peptides are fragile: heat, light, agitation and freeze-thaw cycles all degrade them, and a degraded peptide simply under-delivers with no visible warning

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ALS is characterized by neurodegeneration of motor neurons in brain, spinal cord, and periphery, leading to progressive muscle paralysis: terminal events often comprise aspiration pneumonia and respiratory insufficiency (Morgan and Orrell, 2016

Am J Physiol Gastrointest Liver Physiol 294:G208-216