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In vivo pharmacological manipulation of TRPA1 was not feasible due to the lack of information on the safety and pharmacokinetic profiles of selective agonists and antagonists 89

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In rats, PACAP stimulates GH release from pituitary cell lines and also when infused in vivo (432-434)

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This glucose-dependent mechanism means insulin is released when blood sugar is elevated but not when it is normal, reducing hypoglycemia risk