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The presence of obesity is intricately associated with the risk of ischemic heart diseases [81], associated with a doseresponse relationship[82]

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Gradual dose reduction rather than abrupt cessation may minimize rebound effects, though optimal discontinuation strategies require further study

Type 2 diabetes is common in patients with obesity, and obesity increases production of estrogen hormones to abnormal levels, causing further fluctuation in periods and ovulation along with an increased risk of pregnancy complications and miscarriage

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The protocols below reflect what has been used in published research and what is commonly discussed in clinical peptide practice