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Regardless of these findings, it is known that physiologically, the central and peripheral mechanism commonly co-exist and function synergistically, and are complementary to each other

However, frailty extends beyond elderly to include obesity [156,157,158]

Immunofluorescence staining was performed to analyze tubular and podocyte injuries, localization of ENaC in patients without diabetes who received kidney biopsy for mild proteinuria or microhematuria and those with diabetes mellitus