MC4R activation promotes increased energy expenditure through stimulation of sympathetic nervous system activity, brown adipose tissue thermogenesis, and enhanced fatty acid oxidation
It's particularly compelling for patients who haven't achieved adequate response with semaglutide or tirzepatide, those with obesity and concurrent knee osteoarthritis, patients with metabolic liver disease, and anyone with a significant cluster of cardiovascular risk factors
High protein
These results were groundbreaking at the time of publication and have since been reinforced by subsequent trials
We look forward to working with policymakers, payers, clinicians and patient advocates to ensure that the promise of this announcement is realized in clinical practice including timely access, appropriate coverage, provider education, equitable care, and ongoing support for longterm outcomes. However Dr
Dr Sultan also recommends physician developed supporting supplements that enhance GLP 1 therapy and promote overall metabolic health
