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In the Phase 3 TRIUMPH-1 trial reported in 2026, patients on the 12 mg dose lost an average of 28.3% of their body weight over 80 weeks, compared with just 2.2% for placebo (Eli Lilly, 2026)

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In some cases, increased pressure inside the skull may occur, leading to symptoms like irritability, lethargy, an increase in head size, and nerve problems