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The desensitization phenomenon of GHRP has been reported previously.22, 23, 24, 25, 26 In an animal study using transgenic growth-retarded rats, infusion of GHRP-6 for 7 days produced a dose-dependent increase in body weight gain and accelerated skeletal growth.26 However, this growth promoting effect was observed only in the group infused with GHRP-6 at 3-h pulses
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