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Sublingual administration offers a middle ground: onset at 1530 minutes with bioavailability around 5060%, bypassing hepatic metabolism but still requiring mucosal absorption

This effect is generally modest and clinically meaningful mainly for drugs with narrow therapeutic windows

"Every man desires to live long," wrote Jonathan Swift, "but no man would be old." He was right, but the fountain of youth has proved illusory

W., Ohno, H

That can lead to dangerous heat generation and possibly thermal runaway

While InsR-A homodimer binds both insulin and IGF2 with high affinity, InsR-B homodimer and InsR-A/B heterodimer preferentially bind insulin but not IGF