Hypermelatoninemia is less common, and except for pharmacological effects, few conditions have been associated with high melatonin production: spontaneous hypothermia, hyperhidrosis syndrome, polycystic ovary syndrome, hypogonadotropic hypogonadism, anorexia nervosa, and Rabson-Mendenhall syndrome that induces pineal hyperplasia
Seek veterinary advice if your horse is receiving prescription medication or has significant cardiovascular disease
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Beyond metabolic modulation, more targeted approaches are in development
