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Pharmacokinetic endpoints: if the research objective includes PK characterisation, build in LC-MS quantification of serum peptide at multiple timepoints to generate a concentration-time curve

Telomeres are protective segments of DNA located at the ends of chromosomes

Brain Dev 35:146154 Polster BM, Fiskum G (2004) Mitochondrial mechanisms of neural cell apoptosis

However, in scenarios where the FOXO4 is linked with the DRI peptide, it is suggested that this binding may not occur, potentially allowing p53 to interact with DNA and facilitate the continuation of the cell cycle toward programmed death

doi: 10.1096/fba.2024-00151 Dacquin R, Davey RA, Laplace C, et al

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