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3537 Secondary analyses have shown a possible benefit to tighter control, but this must be balanced against several large and more recent trials of tight control in the United States that showed either no benefit or adverse effects

What the Studies Actually Showed: Preclinical Data Study 1: Fat and Liver Mass Drop Far Faster Than Muscle In diet-induced obese mice treated with tirzepatide (the dual GLP-1/GIP agonist in Mounjaro and Zepbound) for 14 days, researchers found a 73% reduction in body fat and only a 13% reduction in LBM