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2 R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine: a potent, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes
Phase 3: Maintenance (Weeks 9+) Dose: 0.1 mL (10 units) subcutaneous, 2-3x weekly Pulsed administration keeps the repair signal present without turning the protocol into constant stimulation: Signal sensitivity pulsed dosing is the conservative way to avoid blunting the response over time
Common sites include the abdomen, glutes, or thighs
In total, 45 age- and sex-matched healthy participants (mean s.d
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