The molecular mechanism by which the PfK13 mutations confer artemisinin resistance in clinical isolates may involve multiple cellular and metabolic processes, including hemoglobin uptake and digestion, the unfolded protein stress response, mitochondrial functions, oxidative stress responses (including tRNA thiouridine modification reprogramming), and an enhanced DNA damage repair mechanism 3, 811, 1320
Tirzepatide is a large peptide molecule with a specific three-dimensional structure that determines its biological activity
The variation in incidence rates of breast cancer between ethnic groups is already well established, including variations between patient subtypes, age of onset, and survival rates for people of both European, African, and Asian descent (93, 94)
Tirzepatide versus insulin glargine in type 2 diabetes and increased cardiovascular risk (SURPASS-4): a randomised, open-label, parallel-group, multicentre, phase 3 trial
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