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The SELECT trial demonstrated that semaglutide 2.4 mg reduced major adverse cardiovascular events (heart attack, stroke, and cardiovascular death) by 20% in adults with overweight or obesity and established heart disease (Lincoff et al., SELECT trial, New England Journal of Medicine , 2023)

However, there are different ways to target the GLP-1 pathway, where two alternatives are stimulation of the receptor or the enhancing endogenous GLP-1 levels

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This establishes a clear starting point for monitoring during treatment and helps your medical team identify whether your pacemaker settings or underlying rhythm need any adjustment