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It is not clear whether these supraphysiological increases in GLP1 secretion can be sustained over time as our studies are limited to acute responses, though evidence from metabolic surgery suggests the durability of GLP1 output that is sustained for years in human patients (Hutch and Sandoval, 2017)
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I've spent years learning from the work of Benjamin Bikman, Robert Lustig, Jason Fung, Gary Taubes about how metabolism and insulin resistance actually work
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Jardiance family Disease area(s): Metabolic/cardiovascular Manufacturer(s): Boehringer Ingelheim/Eli Lilly and Company 2024 Sales (USD): $12.38 billion Why it sold so well: Co-developed by Boehringer Ingelheim and Eli Lilly, the Jardiance family experienced robust growth in 2024, driven by expanding clinical indications and strong global demand