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BMC Endocr Disord 23 , 13 (2023)

When IGF1 binding to IGF-IR/InsR is blocked by the anti-IGF-IR mAb cixutumumab, IGF1 binding to integrin v3 increases, resulting in activation of v3 and its downstream effectors Src, FAK, and PI3K, which confers cixutumumab resistance [172]

It is being tested to combine ganitumab with Src inhibitor dasatinib in patients with embryonal and alveolar rhabdomyosarcoma, and with chemotherapy, radiotherapy or CDK4/6 inhibitor in Ewing sarcoma (Table 1)

Early in a cycle, many report changes in rest and recovery, which can be an encouraging signal

[PMC free article: PMC9205382] [PubMed: 35733471] 32

The meeting is July 23-24 at FDA's White Oak Campus