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Diabetologia 55:432442 Zema MJ (2012) Colesevelam hydrochloride: evidence for its use in the treatment of hypercholesterolemia and type 2 diabetes mellitus with insights into mechanism of action

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242 UCP1 facilitates proton leakage into the mitochondrial matrix, bypassing ATP synthesis and releasing energy as heat, which is essential for thermoregulation under cold conditions

The y-peptide bond is important for not being degraded by most peptidases in the cell, with the exception of GGTs (gamma-glutamyl transferase) (Ohkama-Ohtsu et al

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A less significant reduction of VAS scoring was observed in the only report of non-diabetic group (MD, 0.71