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After two weeks of Pycnogenol gum usage, the levels of volatile sulfur compounds (hydrogen sulfide, methyl mercaptan and dimethyl sulfide) were significantly reduced compared to baseline and after four weeks, these levels were reduced significantly compared to placebo

A 2023 analysis of the SUSTAIN and PIONEER trials published in Cardiovascular Diabetology showed significant reductions in high-sensitivity C-reactive protein, a marker of systemic inflammation, among patients taking semaglutide

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