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Ferroptosis is characterized by the depletion of intracellular GSH and decreased activity of GPx4, which in turn results in the accumulation of lipid peroxides and Fe(II)-catalyzed oxidation of lipids by the Fenton reaction and increased ROS formation

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Positively charged nanomicelles in water of amphiphilic copolymer chitosangpolylactide as drug carrier of photoporphyrin IX for photodynamic therapy