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The pathogenesis of CRC There are three main mechanisms of CRC carcinogenesis: 1) Accumulation of genetic and epigenetic alterations in CRC stem cell genome

MAPK/ERK drives proliferation

2.12 Involvement of collateral vessel formation in exercise-mediated alleviation of atherosclerosis The ameliorative effect of exercise training on atherosclerosis is manifested not only through the regulation of traditional factors but also via the promotion of collateral vessel formation, which compensates for blood flow in ischemic tissues

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Those are not interchangeable for timing, protocol interpretation, or research design