N Engl J Med 389:10691084
Wang YN, Li XJ, Wang WF, Zou L, Miao H, Zhao YY
Key limitations of current evidence include: Relatively short follow-up periods (typically 35 years) in randomised trials, whereas pancreatic cancer may take years to develop Potential for detection bias, as patients on GLP-1 therapy may undergo more frequent medical monitoring Difficulty accounting for all confounding factors in observational studies Despite these limitations, the weight of current evidence does not support a causal link between GLP-1 receptor agonist use and pancreatic cancer development
This means it doesnt just stop and then start in the next location
Its extended analog profile makes it relevant for studies focused on receptor signaling duration, anabolic pathway models, cellular repair signaling, skeletal muscle biology, and growth-factor pathway research
3.3 Dual role of Se deficiency in cretinism Cretinism often occurs in areas where endemic goiter is prevalent, with mucinous edema cretinism being the main manifestation of hypothyroidism without goiter