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doi: 10.3389/fmed.2023.1124275 Received 14 December 2022 Accepted 27 February 2023 Published 22 March 2023 Volume 10 - 2023 Edited by Ana Sandoval-Rodriguez, University of Guadalajara, Mexico Reviewed by Angelo Armandi, University of Turin, Italy

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Author contributions HE-S: conceptualization, ultrasonographic examination, biochemical analysis, data curation, and manuscript writing

Epitalon effects on melatonin production and circadian rhythm typically persist for 4 to 6 months after a 10 to 20 day cycle, which is why cycles are repeated only 2 to 3 times per year

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