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Receptor endocytosis, an intermediate step toward downregulation, is also necessary for resensitization via dephosphorylation and recycling 11, thus, totally inhibiting endocytosis will likely result in reduced signaling as surface receptors become desensitized via -arrestin recruitment

doi: 10.1016/S2213-2600(19)30198-5, 2

Associations between circulating reproductive hormones and SHBG and prevalent and incident metabolic syndrome in community-dwelling older men: the concord health and ageing in men project

Thus, it could be expected that CR, CHO restriction or other fasting mimicking diets 172 could be effective against tumor growth in humans