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One exception could be gallstone pancreatitis

GLP-1 medication is most effective when combined with nutrition changes, physical activity, strength training, sleep improvement, and long-term behavior planning

Harutyunyan et al., 2021)

When to Speak to Your GP About Energy Changes Whilst mild fatigue during the initial weeks of Ozempic treatment is relatively common, certain symptoms warrant prompt medical review

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doi: 10.1371/journal.ppat.1003436 117 LeibovitzE