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The first head-to-head clinical trial (SURMOUNT-5, published in the New England Journal of Medicine in 2025) showed tirzepatide produced 20.2% average weight loss at 72 weeks compared to 13.7% for semaglutide approximately 47% greater relative weight loss

If the body lacks L-carnitine, it will cause fatty acid metabolism disorder, leading to two consequences

2016 The effect of (L-)carnitine on weight loss in adults Talenezhad et al

Regularly seek support from a healthcare professional, coach, or support group

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