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Patients should also seek medical advice if muscle symptoms are accompanied by systemic features such as fever, unexplained weight loss beyond what is expected from GLP-1 therapy, rash, joint swelling, or other concerning signs that might suggest inflammatory or autoimmune conditions

This can slow metabolic rate and make long-term weight maintenance more difficult

Early clinical research suggests Retatrutide may promote greater fat-mass reduction while preserving lean body mass, which supports healthier body recomposition

Can enhance weight loss results and positively impact overall health

The SELECT cardiovascular outcomes trial showed a 20% reduction in major adverse cardiovascular events